Creative Diagnostics, a leading manufacturer and supplier of antibodies, small molecule conjugates and critical assay reagents for the analysis of food, feed, environmental and toxicological samples, is proud to announce the development of a new series of high-quality test reagents for the detection ofDiacetoxyscirpenol(DAS), a potent mycotoxin. These cutting-edge reagents are designed to enhance food safety and quality control measures.

Diacetoxyscirpenol (DAS), also known as anguidine, is a type A monotrichothecene mycotoxin. It is a secondary metabolite of fungi of the genus Fusarium and is a major contaminant of cereals and cereal-based foods, potentially causing poisoning in farm animals. DAS has been detected in agricultural products worldwide and remains in products after processing. Studies have shown that consumption of diacetoxyscirpenol induces haematological disorders (neutropenia, aplastic anaemia) in humans and animals. The main adverse reaction following acute and repeated exposure to diacetoxycipranol is vomiting.

In addition, DAS can cause many chronic and acute effects in animals and humans, such as immunotoxicity, haematotoxicity, pulmonary disease, growth retardation and cardiovascular effects. It can also damage a variety of organs and tissues, including liver, thymus tissue, brain, seminiferous tubules and epididymis. Additionally, DAS can inhibit the synthesis of proteins and DNA, resulting in oral lesions, decreased feed intake, lower serum iron-binding capacity, gastrointestinal lesions and diarrhoea in in various species including pigs, chickens, rabbits, rats, dogs, and calves.

In 2016, the Joint FAO/WHO Expert Committee on Food Additives (JECFA) evaluated the toxicity of DAS and decided to include DAS in the provisional tolerable daily intake (PTDI) group (WHO/FAO, 2002). To support the accurate and efficient detection of DAS and improve food safety and quality control, Creative Diagnostics now offers a range of sensitive and specific reagents for DAS detection, including Diacetoxyscirpenol Antibodies Antigens, Diacetoxyscirpenol ELISA Kits, and Diacetoxyscirpenol Screen Tests. These reagents are essential components of enzyme-linked immunosorbent assays (ELISA) and lateral flow immunoassays (LFIA), providing rapid and accurate results.

For example, the Diacetoxyscirpenol ELISA Kit (Cat. No DEIASL114) can be used for the quantitative analysis of the DAS in grains. The kit is a competitive enzyme-labeled immunoassay that measures DAS residues extracted from ground grain samples with a 70% methanol/water solution. In addition, the Mouse Anti-Diacetoxyscirpenol monoclonal antibody, clone DAS (CABT-L4607) can recognize the conjugated form of the small molecule. The specificity of the antibody is determined by ELISA using competition experiments.

Creative Diagnostics is striving to develop high quality detection reagents to support the development of mycotoxin detection. By leveraging its expertise in immunoassay development, Creative Diagnostics empowers laboratories and food safety professionals to safeguard public health and maintain stringent quality standards. For more information on the new Diacetoxyscirpenol Test Reagents and other food safety solutions, please visithttps://www.creative-diagnostics.com/food-analysis/diacetoxyscirpenol.html.

About Creative Diagnostics

Creative Diagnostics is a leading manufacturer and supplier of antibodies, small molecule conjugates and critical assay reagents for the analysis of food, feed, environmental and toxicological samples. Its product portfolio covers a wide range of analytes including mycotoxins, drug residues, pesticides, contaminants, food allergens, food pathogens and vitamins. The company also assists customers in the rapid development, manufacture and commercialization of small molecule antigens, antibodies and food safety lateral flow strips for any market segment.

Creative Diagnostics is dedicated to providing researchers with nucleic acid residue assay kits that help manufacturers detect, quantify and control residual host cell DNA, viral vector nucleic acids, recombinant DNA and foreign nucleic acids to ensure the safety, purity and consistency of the final product. By incorporating nucleic acid testing into the quality control process, biopharmaceutical companies can improve the quality and compliance of their products and ultimately protect public health.

The presence of insect DNA can be a significant problem in a variety of industries, particularly biologics manufacturing and food processing. Creative Diagnostics' new Insect Nucleic Acid Residue Assay Kits address this critical need by providing a reliable, efficient method for detecting even trace amounts of insect DNA. These kits use quantitative polymerase chain reaction (qPCR) technology, which provides high sensitivity and specificity for accurate quantification of insect nucleic acid residues. This precision is essential to meet stringent quality control standards and regulatory requirements.

For example, the Sf9 DNA Fragment Residue Assay Kit (Cat. No. DDNA-035) is designed to quantitatively analyze and detect the size distribution of residual Sf9 DNA fragments in a wide range of biological products, including intermediates, semi-finished and finished products. The kit is developed for four different amplification fragments (87 bp, 118 bp, 225 bp, 500 bp) using the PCR fluorescent probe assay principle and is equipped with a reference standard for quantification of Sf9 DNA. This kit is used in conjunction with the Creative Diagnostics Host Cell DNA Pre-treatment Kit.

The ResDetFast Hi5 & AcNPV DNA Residue Assay Kit (Cat. No. DDNAF-033) uses the PCR fluorescent probe method to design primers targeting the conserved genes of Hi5 cells and AcNPV, respectively, which can quantitatively detect the residual DNA of Hi5 cells and AcNPV in the genetically engineered vaccines produced by the insect cell-barcovirus expression system. The kit contains an internal standard to monitor abnormal extraction and amplification and to prevent false negatives.

Creative Diagnostics' mission is to provide cutting-edge tools and solutions for the advancement of scientific research and the improvement of human health. These new Insect Nucleic Acid Residue Assay Kits provide an important tool for ensuring product quality and safety in a variety of industries. For more information on the new assay kits, please visithttps://qbd.creative-diagnostics.com/products/insect-nucleic-acid-residue-assay-kits-qpcr-2794.html.

About Creative Diagnostics

Creative Diagnostics is a global leader in the development and manufacturing of innovative tools and reagents for bioprocess impurity analysis. The company offers a comprehensive portfolio of solutions to support researchers in the quality control of biologics and provides biopharmaceutical quality, purity and safety assays, analytical methods and applications for the biotechnology and biopharmaceutical industries.